Idiopath Thrombocytopenic Purp- ITP (Destructive) Prim Or Second

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  • Idiopath Thrombocytopenic Purp- ITP (Destructive) Prim or Second

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Etiology

  • Atuoimmune destruction of platelets
  • Primary ITP is idiopathic
  • Secondary ITP is related to an underlying process: Hepatitis, HIV, H Pylori; Other autoimmune disorder: SLE, Sjogrens, RA, other; Meds: quinine, quinidine, carbamazepine, rifampin, vancomycin; Cancer: CLL, Hodgkins lymphoma; Immunodeficiency disorders: CVID

Risk Factors

  • Age 20-30, age > 60

Symptoms

  • Mucocutaneous bleeding
  • May be acute or chronic
  • Also increased risk (oddly) of venous thromboembolic disease

Physical Exam Findings

  • No hepato-splenomegaly or other if primary
  • If secondary→ finding of primary d/o
  • Petechiae and mucosal bleeding

Tests

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